Room-temperature alternative to the Arbuzov reaction: the reductive deoxygenation of acyl phosphonates.
نویسندگان
چکیده
The reductive deoxygenation of acyl phosphonates using a Wolff-Kishner-like sequence is described. This transformation allows direct access to alkyl phosphonates from acyl phosphonates at room temperature. The method can be combined with acyl phosphonate synthesis into a one pot, four-step procedure for the conversion of carboxylic acids into alkyl phosphonates. The methodology works well for a variety of aliphatic acids and shows a functional group tolerance similar to that of other hydrazone-forming reactions.
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ورودعنوان ژورنال:
- Organic letters
دوره 12 18 شماره
صفحات -
تاریخ انتشار 2010